A Case of Kikuchi – Fujimoto Disease.

Kikuchi – Fujimoto Disease (KFD) or histiocytic necrotizing lymphadenitis is a rare benign, self-limited cervical lymphadenitis of unknown etiology. Kikuchi first described the disease in 1972 in Japan. Fujimoto and colleagues independently described Kikuchi’s disease in the same year. It pre-dominantly affects young women and can closely mimic infective and immunological disorders. In this article a case of KFD in a young female is described.

Childhood kikuchi-fujimoto disease.

To investigate the clinical features of Kikuchi-Fujimoto disease (KFD) and the relationship between viral infection and this disease in children will be better as Kikuchi-Fujimoto disease (KFD) is a lymphadenopathy. The aim of study is to investigate the clinical features of KFD and the relationship. The age, gender, clinical features and aetiopathogenesis of 36 Chinese children with FKD were reviewed, and the viral antigens were detected. Mean age was 10.1 ± 2.8 yr with a male to female ratio of 1.8:1. Fever and lymphadenopathy were the most common complaints, noted in 23 and all cases respectively. Skin rash and hepatosplenomegaly were also noted. Leukopenia, anemia, thrombocytopenia and raised ESR were noted in 21, 6, 4 and 31 cases respectively. Epstein-Barr virus (EBV) IgM and IgG was positive in 1 and 24 of 29 cases respectively. Antigens of EBV and herpes simplex virus 2 (HSV 2) were found in the biopsy tissue section from 2 and 1 case respectively. Autoantibodies were noted in 3 of 15 cases. Steroid hormones were administrated for 19 cases with good efficacy. These results imply that children with lymphadenopathy and/or fever may have KFD and thus excisional biopsy of lymph nodes should be performed earlier on. A hyperimmune reaction of immune cells to EBV and HSV2 may play a role in the pathology of KFD.

Enfermedad de Kikuchi - Fujimoto: reporte de un caso / Kikuchi - Fuijimoto disease: report a case

La enfermedad de Kikuchi o Kikuchi Fujimoto o linfadenitis histiocítica necrotizante, es una rara y habitualmente benigna enfermedad que se presenta con fiebre y adenopatías cervicales usualmente en mujeres jóvenes. La etiología es desconocida, aunque hay evidencias de su origen viral y la semejanza del grupo poblacional afectado con el lupus eritematoso sistémico ha alentado, en base a estudios celulares, la sospecha de que el síndrome de Kikuchi refleja una condición Lupus - símil auto limitada y causada por linfocitos transformados por una infección viral. Inicialmente descripta en Japón, la enfermedad de Kikuchi Fujimoto se ha reportado en diferentes grupos étnicos y raciales, aunque ha sido predominantemente descripto en Asia. La enfermedad puede ser sospechada por la clínica pero se necesita de la anatomía patológica para su confirmación.

Histiocytic necrotizing lymphadenitis (Kikuchi's disease): clinicopathologic characteristics of 23 cases and literature review.

Kikuchi's disease or histiocytic necrotizing lymphadenitis is a self limiting disorder which usually affects young women and manifests clinically by cervical lymphadenopathy with or without fever. Though the disease has been described since 1972, many clinicians and pathologists are unaware of its existence. We therefore reviewed 23 cases of Kikuchi's disease in Songklanagarind Hospital from 1987 to 1996. Clinical data, histopathology including immunostaining were presented together with brief literature review. We found 18 women and 5 men with the age range 9-57 years. The sites of nodal enlargement were cervical in 17, axillary in 3 and unknown in 3 cases. Typical histologic features namely patchy paracortical lymphohistiocytic aggregates with variable karyorrhexis and absence of granulocytic infiltration were seen. Immunostaining confirmed that the principle cells were histiocytes and T-lymphocytes. Importance in the recognition of the entity was emphasized for it may be mistaken for other infective lymphadenitis or lymphoma.